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Eli Lilly strikes Zepbound deal with Ro, amid questions on compounded GLP-1s
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Molecular Biology
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Analyzing molecular recognition of retatrutide by GLP-1R, GIPR and GCGR highlights that the triple agonism is achieved through a combination of maintaining common interactions with conserved residues and accommodating receptor-specific residues with variable contacts primarily in the upper half of the TMD pocket (Fig
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